Zoom Webinar:
Implementing Evidence-based Antimicrobial Prescribing to Combat AMR and Strengthen Global Stewardship – The GUIDE Framework in Action
Monday, 17 November 2025, 12:00-13:00 CET/11:00-12:00 UK/06:00-7:00 EDT/15:30-16:30 IST
Join us for the launch of a new evidence-based tool to enhance antimicrobial prescribing and stewardship. Share your feedback to help us strengthen its value and usability for global practice.
The GUIDE Framework for Evidence-based Antibiotic Prescribing
Strengthening Antimicrobial Stewardship for the Healthcare Workforce
By Dr. Rasha Abdelsalam Elshenawy
Antimicrobial resistance (AMR) poses a critical threat to global health security, with inappropriate antibiotic prescribing in hospitals driving the spread of resistant pathogens. This GUIDE Framework for Evidence-Based Antibiotic Prescribing provides a structured, five-step model designed to strengthen antimicrobial stewardship (AMS) and empower the healthcare workforce to make informed, proportionate prescribing decisions.
South Centre Statement to the Intergovernmental Working Group (IGWG) on the WHO Pandemic Agreement
3 November 2025
This statement was delivered at the opening of the Intergovernmental Working Group (IGWG) on the WHO Pandemic Agreement, third session, on 3 November 2025. The South Centre underscored that the first draft Bureau text helps to kick off text-based negotiations, but it does not meet the requirements for implementation of Article 12 of the Pandemic Agreement.
12th Session of the Expert Mechanism on the Right to Development (EMRTD)
27-29 October 2025, Geneva
International Trade & Health Conference 2025
Co-organized by the National Commission on International Trade & Health Studies (NCITHS), Thailand together with the International Trade & Health Programme (ITH), South Centre & other partners
When: 28-29 October 2025
Where: Movenpick BDMS Wellness Resort, Bangkok & online
Advancing Responsible Foreign Investment through a Legally Binding Instrument on Transnational Corporations and Other Business Enterprises
By Daniel Uribe Terán
Foreign Direct Investment (FDI) presents a complex dynamic, offering potential economic growth while posing significant risks of human rights abuses and environmental degradation. This policy brief considers that current voluntary frameworks, such as Economic, Social, and Governance (ESG) and voluntary due diligence standards, are insufficient to protect human rights, as they primarily focus on mitigating investor financial risk rather than preventing actual harm. Furthermore, the international investment regime, particularly the Investor-State Dispute Settlement (ISDS) mechanism, systemically undermines States’ sovereign right to regulate in the public interest. ISDS cases often penalise governments for enacting environmental, labour, and human rights protections, creating a “regulatory chill” that prioritises corporate profits over social welfare. The proposed Legally Binding Instrument (LBI) on business and human rights is presented as a necessary response to establish mandatory, enforceable obligations for corporations. This includes robust Human Rights Due Diligence (HRDD) and legal liability mechanisms, thereby rebalancing the system to ensure corporate accountability and align investment with sustainable development goals.
A Revolution in HIV/AIDS Treatment
By German Velasquez
On September 24, 2025, two agreements were announced with generic drug manufacturers in India for the supply of generic lenacapavir at $40 (instead of the original $28,218) per patient per year. However, these generics can only be supplied to the countries included in Gilead’s voluntary license, excluding too many from accessing this price.
The negotiations on the Pathogen Access and Benefit Sharing System under the WHO Pandemic Agreement: State of Play as of September 2025
By Viviana Munoz Tellez, German Velasquez
The World Health Organization (WHO) Member States adopted a Pandemic Agreement in May 2025 but deferred negotiations on the critical Pathogen Access and Benefit Sharing System (PABS). Despite the tight timeline, the Intergovernmental Working Group (IGWG) has made minimal progress as of September 2025, with no draft text produced and formal negotiations yet to begin. The PABS system is essential for pandemic equity, balancing rapid pathogen sharing with equitable access to vaccines and treatments. But with the current approach to the IGWG process, without formal negotiations underway, Member States risk failing to finalize the PABS Annex by the March 2026 deadline.
Negotiating Global Health Policies
Tensions and Dilemmas
Description:
This book presents reflections and research that highlight tensions in the negotiations on pandemic preparedness treaties and revisions to the International Health Regulations, underscoring the geopolitical divide between developed and developing countries. It advocates regional health initiatives as a response to the multilateral impasse and reflects on the erosion of foundational public health concepts such as “essential medicines”.
New pandemics are inevitable. How can we best prepare for them and, above all, how can we avoid the mistakes and injustices made during the COVID-19 pandemic?
How can equitable access to medicines and diagnostics be guaranteed when they are produced in a small number of countries? How can we explain the fact that current funding for cooperation in the field of health is in the hands of a small group of Northern countries and foundations from the North? How can the role of the World Health Organization be strengthened? WHO now plays only a minor role in coordinating public health policies. How is it that the concept of “essential medicines”, a major advance in public health policy, is being replaced by that of “medical countermeasures”, a term more in line with the private sectors?
Preparing for future pandemics forces us to ask ourselves: how can we safeguard the general interest, the defense of human rights and public health?
Negotiating Global Health Policies: Tensions and Dilemmas is essential reading for negotiators from the 194 member countries of the World Health Organization (WHO), the World Trade Organization (WTO), and the World Intellectual Property Organization (WIPO) who participate in international negotiations on health and development. Academics and students of medicine, health sciences, law, sociology and political science, as well as intergovernmental organizations and non-governmental organizations who work on access to medicines and global health issues, also would find the book of interest.
Author: Germán Velásquez is Special Adviser, Policy and Health of the South Centre in Geneva, Switzerland. Previously, he was Director of the Secretariat on Public Health, Innovation and Intellectual Property at WHO. He represented WHO at the WTO TRIPS Council from 2001 to 2010. He is the author and co-author of numerous publications on health economics and medicines, health insurance schemes, globalization, international trade agreements, intellectual property and access to medicines.
He obtained a Master’s degree in Economics and a PhD in Health Economics from Sorbonne University, Paris. In 2010, he received a Honoris Causa PhD on Public Health from the University of Caldas, Colombia and in 2015 he received another Honoris Causa PhD from the Faculty of Medicine of the Complutense University of Madrid, Spain.
Implementing the 2024 AMR Political Declaration: Industry Accountability and Equity in Agrifood Sector Transformation
By Dr. Viviana Munoz Tellez
On 2 July 2025, at the sides of the Food and Agriculture Organization (FAO) Conference, a high-level dialogue on AMR was held, co-organized by the Governments of Kenya and the United Kingdom (co-chairs of the Group of Friends of AMR), the South Centre, FAO, and the AMR Multi-Stakeholder Partnership Platform. The event took place at the FAO Headquarters in Rome, with in-person participation and webcast. Ambassadors and senior officials of Kenya, South Africa, India and Brazil, among others, made interventions in the high-level segment. The South Centre was also part of the panel.
The theme of the event “Industry Accountability and Equity in Agrifood Sector Transformation” provided an opportunity for forward-looking dialogue on the urgent need to transform how antimicrobials are used in agrifood systems, and the government’s required leadership in developing and implementing national policy frameworks that are adapted to national contexts, priorities and needs to address AMR and in adopting measures to incentivize responsible practices in the agrifood sector.
New Amendments to the International Health Regulations: Strengthening Access to Health Products in Emergencies and Pandemics
By Viviana Munoz Tellez
The International Health Regulations amendments entered into force on September 19, 2025 across most World Health Organization (WHO) Member States. These updates don’t give WHO any new powers but help countries work better together to advance fair and timely access to health products such as vaccines, treatments and diagnostics needed to respond to health emergencies. The real challenge now is implementation and building the necessary capabilities to make these improvements function.
South Centre Statement during the 60th Session of the United Nations Human Rights Council
General Debate under Item 3
Geneva, 19 September 2025
At the 60th session of the Human Rights Council (HRC60), the South Centre delivered a statement welcoming the crucial update to the technical guidance on preventable maternal mortality and morbidity.
We are encouraged that the guidance moves beyond technical corrections to address the deep-seated root causes of why women and girls still die during childbirth. In our statement, we highlighted several key advancements:
🔹 An Intersectional Approach: The guidance rightfully identifies structural racism and discrimination as fundamental factors, providing a strong basis for targeted interventions.
🔹 A “Human Rights Economy” Framework: It broadens accountability to international financial institutions and corporations, emphasising that the global financial architecture—including sovereign debt, austerity measures, and healthcare privatisation—must be reformed to prioritise human rights.
🔹 Accountability and Reparations: The call for independent accountability mechanisms and a reparation fund for victims correctly reframes preventable maternal deaths from unfortunate accidents to serious injustices requiring systemic solutions.
These principles are intrinsically linked to the realisation of the Right to Development. A global environment that respects this right is essential for funding public health and creating societies where women and girls can thrive.
The challenge now is implementation. We call on all states, international financial institutions, and partners to fully fund and realise this new, rights-based and justice-oriented guidance.
