AWaRe Classification

SC Guide Framework for Evidence-based Antibiotic Prescribing, November 2025

The GUIDE Framework for Evidence-based Antibiotic Prescribing

Strengthening Antimicrobial Stewardship for the Healthcare Workforce

By Dr. Rasha Abdelsalam Elshenawy

Antimicrobial resistance (AMR) poses a critical threat to global health security, with inappropriate antibiotic prescribing in hospitals driving the spread of resistant pathogens. This GUIDE Framework for Evidence-Based Antibiotic Prescribing provides a structured, five-step model designed to strengthen antimicrobial stewardship (AMS) and empower the healthcare workforce to make informed, proportionate prescribing decisions.

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