WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS)
Meeting the 2030 Target on Reducing the Global Burden of AMR: Pathways for Strengthening and Leveraging Surveillance in Developing Countries
By Prateek Sharma and Viviana Munoz Tellez
Antimicrobial Resistance (AMR) poses a major and growing threat to global health, yet low- and middle-income countries (LMICs) face significant challenges in implementing AMR surveillance –collection and analysis of data on AMR. Global AMR targets, including the United Nations’ goal of reducing AMR-associated deaths by 10 percent by 2030 and achieving diagnostic capacity in 80 percent of countries, rely on surveillance data that are often incomplete, hospital-centered, and unrepresentative of community infections in LMICs. While the Global Antimicrobial Resistance and Use Surveillance System (GLASS) of the World Health Organization (WHO) provides a standardized framework, in LMICs limited access to diagnostics, high laboratory costs, and reliance on data from specialized hospitals constrain participation and data comparability. Modeling studies have helped quantify the global burden of AMR, yet their reliance on sparse LMIC data underscores the need for improved primary surveillance. Achieving the United Nations’ 2030 target—where 80 per cent of countries can test resistance in all GLASS pathogens—will require substantial investment, technical support, and sustained political commitment. Embedding AMR surveillance within health systems and strengthening pandemic prevention and preparedness can help unlock external funding for eligible LMICs through the Pandemic Fund and the Global Fund.
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Participation of South Centre Member Countries in the WHO GLASS: Progress and Gaps in AMR Surveillance and Stewardship Efforts
By Dr. Rasha Abdelsalam Elshenawy
This study highlights antimicrobial resistance (AMR) surveillance challenges in LMICs, focusing on the 55 South Centre Member States’ enrolment in the WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS). Despite progress since its 2016 launch, significant gaps persist: only 60 percent of South Centre Member States report AMR surveillance to GLASS, and just 38 percent report antimicrobial use (AMU) data to GLASS. The COVID-19 pandemic substantially disrupted surveillance activities, with rates declining from 2020-2021 compared to pre-COVID-19 pandemic levels. Digital infrastructure, such as mobile reporting tools, cloud-based systems, and interactive dashboards, offers significant opportunities to strengthen AMR surveillance in resource-limited settings. The study recommends a holistic and phased approach for South Centre Member States, including developing integrated national AMR action plans with realistic implementation timelines, investing in laboratory and workforce development, establishing interoperable digital infrastructure, and strengthening regional collaboration mechanisms. By systematically addressing core surveillance challenges while strategically incorporating digital innovations where appropriate, countries can develop resilient monitoring systems that support effective stewardship, protect national populations, and contribute to global health security by preserving antimicrobial effectiveness for future generations.
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